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Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity

Received: 15 November 2013     Published: 20 February 2014
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Abstract

Electrocortical group neuron activity describe changes in neurotransmision cause by different factors. Such changes could by qualitative described by spectral analysis of electrocortical activity as a variation of relative spectral power in different frequency ranges. We used fractal dimension to compare treated animals with control to quantitativily describe degree of pathophysiological state. The aim of this study was to qualitativily and quantitatively evaluate effect of the stress and the neurodegeneration in animal model of chronic intoxication by aluminum. This animal model is comparible with Alzheimer’s disease and Parkinson disease. By spectral and fractal analysis we described changes in electrocortical activity of aluminum intoxication compare to physiological control. We used adult animals, during 6 weeks intraperitonealy treated with aluminum. Stress was cause by experimental treatmant and immobilization. Neurodegeneration was observed histologicaly. Results shows that decrease in delta range of spectral power and fractal dimension might be used for evaluation of pathophysiological state of stress and neurodegeneration.

Published in American Journal of BioScience (Volume 2, Issue 2)
DOI 10.11648/j.ajbio.20140202.11
Page(s) 28-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Aluminium , Neurotoxicity, Neurodegeneration, Stress

References
[1] Martać, Lj., Kesić, S., Ćulić, M., Grbić, G., Spasić, S., Sekulić, S., Lalošević, D, (2006). Effect of aluminium neurotoxicity on rat brain activity. Acta Physiol. Pharmacol. Serbica 42, 219-225.
[2] V.B.Gupta,S.Anltha.,M.L.Hegde.,L.Zecca,R.M.Garruto,R.Ravid,K.Shankar,R.Stein,P.Shanmugavelu, K.S.J. Rao (2005). Aluminum in Alzheimers disease:are we still at a crossroad. Cell.Mol.Life.Sci 143-158.
[3] Adler CH (1999). Differential diagnosis of Parkinson desease. Med.Clin.North.Am.83>349-367
[4] He Y.,Chen Z.,Gong G.,Evans A.(2009). Neuronal networks in Alzheimer’s Disease. Neuroscientist 15 (4):333-50
[5] J.L.W.Bosboom.,D.Stoffers.,C.J.Stam.,B.W.van Dijk.,J.Verbunt.,H.W.Berendse and E.Ch.Wolters (2006). Resting state oscillatory brain dynamics in Parkinson’s disease. An MEG study.Clinical Neurophysiology 2521-2531.
[6] Culic M.,Martac Lj.,Grbic G.,Kesic S.,Spasic S.,Sekulic S., Lalosevic D.,Capo I. (2007). Aluminum toxicity in rat brain: Electrophysiological,histological and behavioral evidence. In: From Basic Control to Functional Recovery V (Ed. N.Gantchev),pp. 224-229, Sofia.
[7] Ćulić, M., Blanuša, Lj., Grbić, G., Spasić, S., Janković, B., Kalauzi, A., 2005. Spectral analysis of cerebellar activity after acute brain injury in anesthetized rats. Acta Neurobiol. Exp. (Wars) 65, 11-17.
[8] Bharathi P. et all (2008): Molecular toxicity of aluminium in relation to neurodegeneration. Indian J.Med. Res.,128,545-556.
[9] Campbell and S.C. Bondy, (2000): Aluminum induced oxidative events and its relation to inflammation: A role for the metal in Alzheimer’s disease. Cell. Mol. Biol. 46 , pp. 721–730.
[10] Kawahara M. (2005): Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases. J.Alzheimers Dis. 8,(2),171-82
Cite This Article
  • APA Style

    Ljiljana Martać, Jelena Podgorac, Slobodan Sekulić, Ivan Čapo. (2014). Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity. American Journal of BioScience, 2(2), 28-31. https://doi.org/10.11648/j.ajbio.20140202.11

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    ACS Style

    Ljiljana Martać; Jelena Podgorac; Slobodan Sekulić; Ivan Čapo. Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity. Am. J. BioScience 2014, 2(2), 28-31. doi: 10.11648/j.ajbio.20140202.11

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    AMA Style

    Ljiljana Martać, Jelena Podgorac, Slobodan Sekulić, Ivan Čapo. Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity. Am J BioScience. 2014;2(2):28-31. doi: 10.11648/j.ajbio.20140202.11

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  • @article{10.11648/j.ajbio.20140202.11,
      author = {Ljiljana Martać and Jelena Podgorac and Slobodan Sekulić and Ivan Čapo},
      title = {Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity},
      journal = {American Journal of BioScience},
      volume = {2},
      number = {2},
      pages = {28-31},
      doi = {10.11648/j.ajbio.20140202.11},
      url = {https://doi.org/10.11648/j.ajbio.20140202.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140202.11},
      abstract = {Electrocortical group neuron activity describe changes in neurotransmision cause by different factors. Such changes could by qualitative described by spectral analysis of electrocortical activity as a variation of relative spectral power in different frequency ranges. We used fractal dimension to compare treated animals with control to quantitativily describe degree of pathophysiological state. The aim of this study was to qualitativily and quantitatively evaluate effect of the stress and the neurodegeneration in animal model of chronic intoxication by aluminum. This animal model is comparible with Alzheimer’s disease and Parkinson disease. By spectral and fractal analysis we described changes in electrocortical activity of aluminum intoxication compare to physiological control. We used adult animals, during 6 weeks intraperitonealy treated with aluminum. Stress was cause by experimental treatmant and immobilization. Neurodegeneration was observed histologicaly. Results shows that decrease in delta range of spectral power and fractal dimension might be used for evaluation of pathophysiological state of stress and neurodegeneration.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity
    AU  - Ljiljana Martać
    AU  - Jelena Podgorac
    AU  - Slobodan Sekulić
    AU  - Ivan Čapo
    Y1  - 2014/02/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajbio.20140202.11
    DO  - 10.11648/j.ajbio.20140202.11
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
    SP  - 28
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20140202.11
    AB  - Electrocortical group neuron activity describe changes in neurotransmision cause by different factors. Such changes could by qualitative described by spectral analysis of electrocortical activity as a variation of relative spectral power in different frequency ranges. We used fractal dimension to compare treated animals with control to quantitativily describe degree of pathophysiological state. The aim of this study was to qualitativily and quantitatively evaluate effect of the stress and the neurodegeneration in animal model of chronic intoxication by aluminum. This animal model is comparible with Alzheimer’s disease and Parkinson disease. By spectral and fractal analysis we described changes in electrocortical activity of aluminum intoxication compare to physiological control. We used adult animals, during 6 weeks intraperitonealy treated with aluminum. Stress was cause by experimental treatmant and immobilization. Neurodegeneration was observed histologicaly. Results shows that decrease in delta range of spectral power and fractal dimension might be used for evaluation of pathophysiological state of stress and neurodegeneration.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Department of Neurophysiology, Institute for Biological Researches “Sini?a Stankovi?”, University of Belgrade, Belgrade, Serbia

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